Dangerous Entrapment for NRF2

Dangerous Entrapment for NRF2

Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.

Entrapment.

dangerous toys for teenagers: air weapons

conclusions air weapons can cause serious injuries among children. increased public awareness, limitations to their usage and strict legislation are needed to protect children. case presentation the medical records of four teenage boys shot by air weapons between january 2012 and january 2013 in mersin, turkey, were retrospectively reviewed in this study. of the four boys, two needed prompt tho...

Preparing drivers for dangerous situations

Shared control (also known as continuous haptic guidance or haptically active controls) has recently been introduced in car driving. With shared control, the driver receives continuous force feedback on the gas pedal or steering wheel, so that human and machine conduct the driving task simultaneously. Experiments in driving simulators have shown that shared control reduces control variability a...

Entrapment Neuropathies

Peripheral neuropathy is defined as deranged function and structure of peripheral, motor, sensory, and autonomic neurons, involving either the entire neuron or selected levels. The major categories of peripheral neuropathies are seen in Table 28-1. Because this chapter is concerned with nerve problems seen in the foot that are most amenable to local treatment, only the last four categories are ...